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Article
Insight on the Side Effects of Lipid Lowering Agents (Statin) in Iraqi Patients with Ischemic Heart Diseases

Author: Basil N. Saeed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 3 Pages: 266-269
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:3-hydroxy-3methyl glutaryl co enzyme inhibitor (MMG-COA) (statin) is a very common drug used in many medical conditions regardless of the presence or absence of dyslipidemia. One of these conditions is the cardiac disorders.OBJECTIVE:Throwing a light on the prevalence of their side effects in Iraqi patients.PATIENTS AND METHODS:Two hundred seventy patients with ischemic heart disease from the period of November 2006-November 2007 referred to Baghdad teaching hospital (the medical city). Those cases were using statin and grouped into two groups.Group A: patients admitted with acute coronary syndrome (myocardial infarction and unstable angina) (230 patients 77%).Group B: patients with associated risk factors (Hypertension, diabetes mellitus, smoking and secondary lipidemia) 40 cases 23%, have history of ischemic heart disease on treatment they use the drug in range of (10-40) daily with review monthly for the side effects. All 270 cases were free from other organic disorders (i.e. renal, thyroid, malignancy, or any longstanding disease). All patients went through a questionnaire which includes: age, gender, risk factors (Hypertension, diabetes mellitus, smoking, and lipidemia), routine blood tests, lipid profile, liver function tests, C-reactive proteins, thyroid function tests, chest X-ray, electrocardiography and echocardiography done for all patients, all patients used to take drugs in the range of 10-40mg daily for at least one year.RESULT:The side effects noticed in this study were gastric, musculoskeletal, elevated liver enzymes (40%, 28.9%, and 1% respectively from the total number of patients). Other side effects in other systems like skin, respiratory, and cardiac were not encountered.CONCLUSION:This study showed that the side effects of statin were not involving all the body systems.


Article
Electrochemical Study for the Effect of Simvastatin and Atorvastatin on Coenzyme Q10 by Differential Pulse Polarography Using Mercury Drop Electrode
دراسة كهروكيميائية لتآثرالسيمفاستاتين والأتورفاستاتين مع مساعد الانزيم Q10 بواسطة البولاروغرافيا النبضية المشتقة بأستخدام قطب الزئبق المتقاطر

Author: Sahil A. Alasaddy ساحل عبد الحسين غفوري الأسدي
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 3A Pages: 1811-1820
Publisher: Baghdad University جامعة بغداد

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Abstract

Statin drugs act by inhibiting the enzyme HMG-CoA reductase which is responsible for manufacture of cholesterol and the biosynthesis essential energy production Co-factor (Coenzyme Q10). The aim from this research includes study the effect of statin drugs (Simvastatin and Atorvastatin) on the Coenzyme Q10 using differential pulse polarographic technique at a dropping mercury electrode (DME) and in a mixture of [4:1] methanol-phosphate buffer of pH7.0 as supporting an electrolyte. Prior to this, the behaviors of Simvastatin, Atorvastatin and Coenzyme Q10 were studied separately in their solvents. The half-wave potential (E1/2) of Co Q10 were -0.31volt and -1.37Volt, -1.33 Volt for simvastatin and atorvastatin respectively. A mixture of Coenzyme Q10 with Simvastatin and Atorvastatin in the same solvent shows a shift in their peak potential (Ep) toward more negative potentials values by (-0.06volt) for Simvastatin and by (-0.09volt) by Atorvastatin.

تعمل ادوية الستاتينات على تثبيط انزيم HMG-CoA reductase وهو الأنزيم المسؤول عن تصنيع الكوليسترول والتركيب الحيوي لأنتاج الطاقة Coenzyme Q10. ويتضمن هذا البحث دراسة تآثر ادوية الستاتينات (السيمفاستاتين و الأتروفاستاتين) على مساعد الأنزيم Q10 باستخدام تقنية البولاروغرافيا النبضي المشتق عند قطب الزئبق المتقاطروالمذاب كل منهما في مزيج من الميثانول والمحلول المنظم الفوسفاتي pH7.0 كألكتروليت ساند بنسبة [1:4]. وقبل دراسة التآثر, درس سلوك كل من ادوية الستاتينات ومساعد الأنزيم Q10 بصورة منفصلة في محاليلهما وتم تعيين جهد القمة لمساعد الأنزيم وكانت بقيمة -0.31Voltو بقيمة -1.37Volt, -1.33Volt لكل من السيمفاستاتين والأتروفاستاتين. وتبين ان خليط ادوية الستاتينات مع مساعد الأنزيم Q10 في نفس المذيب ادى الى ازاحة في قيم جهد القمة لمساعد الأنزيم Q10 نحو قيم اكثر سالبية وكانت بمقدار-0.06Volt بالنسبة للسيمفاستاتين و بمقدار -0.09Volt بالنسبة للاتروفاستاتين.

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