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Transurethral management of bladder cancer (2003-2008) at Department of urology, Azadi teaching hospital in Kirkuk city, Iraq.
إدارة الإصابة بسرطان المثانة عبر الاحليل (2003-2008) في قسم جراحة المسالك البولية، المستشفى التعليمي آزادي في مدينة كركوك، العراق.

Author: Muhammad Abdullah Rahman alshwani
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2013 Volume: 19 Issue: 1 Pages: 159-163
Publisher: Tikrit University جامعة تكريت

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Abstract

Introduction: Bladder cancer is a malignant tumor that is rising on scale of awareness of both patients and physician. Aim of the study: To compare age groups, sex group, grading and staging for the patients with bladder cancer treated with transurethral resection in Azadi general hospital, in Kirkuk city in Iraq. Material and methods: Data was obtained from operating protocols, patient’s history and ambulance charts of 140 patients in Azadi general hospital in Kirkuk city in Iraq. Results: Total of 140 patients were operated at our department in given period of time by means of transurethral resection for bladder cancer. Of those 112 (80%) were males and 28 (20%) female patients. Average age for males were (66,07 years) and for the females were (67.82 years) Most common grade was grade 2 in all patients and also when looked in new cases and in patients taking treatment (received cases). Staging showed that most cases were in Ta group, both new or receive cases. And the most common type of tumor resected was Transitional cell carcinoma. Discussion and conclusion: Incidence of bladder cancer is not very high, but it is on constant rise. Bladder cancer is more common in males; Transitional cell carcinoma is more common type of tumor while gradeII and stage Ta are more common findings in our patients.

مقدمة: سرطان المثانة هو ورم خبيث أن يرتفع على نطاق و الوعي لكل من المرضى و الأطباء . الهدف من الدراسة : لمقارنة الفئات العمرية ، والجنس الجماعي ، والتدريج و التدريج لل مرضى الذين يعانون من سرطان المثانة عبر الاحليل استئصال تعامل مع المستشفى العام في آزادي ، في مدينة كركوك في العراق. المواد و الطرق : تم الحصول على البيانات من بروتوكولات التشغيل ، والتاريخ المريض و الرسوم البيانية الإسعاف من 140 مريضا في مستشفى آزادي العام في مدينة كركوك في العراق. وتم تشغيل إجمالي 140 مريضا في قسمنا في فترة معينة من الوقت عن طريق استئصال المثانة عبر الاحليل لسرطان : النتائج. 112 من هؤلاء ( 80 ٪ ) من الذكور و 28 ( 20 ٪ ) من المرضى الإناث. كان متوسط ​​العمر للذكور ( 66،07 عاما) و للإناث كانت ( 67.82 عاما ) كان الأكثر شيوعا الصف الصف 2 في جميع المرضى و أيضا عندما نظرت في الحالات الجديدة وفي المرضى الذين يتناولون العلاج ( الحالات التي وردت ) . أظهرت التدريج أن معظم الحالات كانت في مجموعة تا، سواء الجديدة أو استقبال الحالات. و كان النوع الأكثر شيوعا من سرطان الخلايا السرطانية مقطوعة الانتقالية . المناقشة و الاستنتاج : حالات الإصابة بسرطان المثانة ليست عالية جدا، ولكن كان على الارتفاع المستمر . سرطان المثانة هو أكثر شيوعا في الذكور ؛ سرطان الخلايا الانتقالية هو نوع أكثر شيوعا من الأورام حين gradeII ومرحلة تا هي نتائج أكثر شيوعا في المرضى الذين لدينا.


Article
INTRAVESICAL MITOMYCIN C INSTILLATION TO DELAY RECURRENCE OF SUPERFICIAL BLADDER CANCER (LONG-TERM VERSUS SHORT-TERM PROTOCOLS)

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Abstract

BackgroundMajority of patients with bladder cancer present with superficial tumor, which is of three types: papillary carcinoma confined to the bladder epithelium, tumor invading but confined to the lamina propria, and carcinoma in situ (cis). Transurethral resection represents the effective management of superficial tumors but with high recurrence rate (75%) that can be minimized to 50% by using cytotoxic drug or immunotherapy.ObjectiveTo compare two method lines of treatment in respect to long - term versus short - term therapy of Mitomycin C (MMC)Intravesical instillation after transurethral resection of superficial transitional carcinoma of urinary bladder to detect the duration of disease free interval, recurrence rate and adverse effects.MethodsA prospective, randomized, two parallel and compared lines of treatment study involved 50 patients who were evaluated after transurethral resection of superficial bladder cancer with median follow-up of 30 months. They were informed about the study and their approval to participate in the study was taken. Group A (25 patients) received intravesical MMC 30 mg weekly for 6 weeks, while group B (25 patients) continue to receive further 12 monthly instillations. Statistical analysis was performed by using Kaplan - Meier methods and chi square test.ResultsAfter follow-up of 30 months, 28% of patients who received short course of intravesical MMC were disease free in comparison to those with long – term treatment in group B which shows significantly higher rate of disease free (56%). Regarding the adverse effects, no significant differences in incidence were noted between two groups.ConclusionThe data from the present study confirm both efficacy and safety of using intensive, prolong regimen of intravesical MMC instillation for superficial bladder cancer.Key wordsMitomycin C, superficial transitional carcinoma, and transurethral resection.


Article
Effectiveness of Immediate Mitomycin C Instillation in Patients with Low Risk Non-Muscle Invasive Bladder Cancer

Authors: Usama Sulaiman Al-Nasiri --- Wisam Ali Kareem
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 4 Pages: 387-392
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

BACKGROUND:We determined if immediate instillation chemotherapy after transurethral resection (TUR) decrease the risk of recurrence andor progression in patient with stage Ta T1 bladder cancer.OBJECTIVES:This study has been designed to analyze the impact of a single immediate mitomycin C instillation after transurethral resection of bladder cancer on recurrence and progression rates in patients with low risk superficial bladder cancer.METHODS:A total of 50 patients with low risk superficial bladder cancer were included in a prospective randomized controlled trial. All patients had a 3 cm. or less single, papillary bladder tumer. The tumor was completely resected before patients were randomized into 2 arms of no further treatment (control group) and a single immediate instillation (usually within 6 hours) of 40 mg. mitomycin c (mitomycin c group). Median follow up was 24 months .The events studied were the recurrence free rate, the recurrence rate/year, and the number of new tumors developing /year.RESULTS:At 24-month follow-up the recurrence-free rate was significantly increased (84.7% VS 54.2%). Recurrence (15.3% VS 45.8%), and recurrence per year rate (7% VS 20%) and tumor per year rate(11% VS 33%) were significantly decreased in the mitomycin c compared to the control group.CONCLUSION:This study confirms the positive effect of a single immediate mitomycin C instillation in patients with low risk superficial bladder cancer. Thus, this approach is an alternative to observation. This study also suggests cell implantation as a mechanism of early recurrence can be controlled with a single immediate mitomycin c instillation.


Article
A RANDOMIZED PROSPECTIVE STUDY COMPARING THE EFFECTIVENESS OF MITOMYCIN C AND MITOMYCIN/S2 COMPLEX SEQUENTIAL INTRAVESICAL THERAPY FOR SUPERFICIAL BLADDER CANCER
دراسة عشوائية مستقبلية لتأثير علاج مايتومايسين سي مع مايتومايسن سي بالمقارنة مع مايتوماسين سي/ مركب س2 متعاقب لغسل المثانة في سرطان المثانة السطحي

Authors: Mahmood H. Hammash محمود حياوي حماش --- Abdul-Wahab R. Hamad عبدالوهاب رزوقي حمد --- Ahmad A. Al-Azawi أحمد العزاوي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2005 Volume: 4 Issue: 1 Pages: 72-76
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Objective: Comparison of two protocols regarding efficacy and toxicity of intravesical mitomycin C versus mitomycin C and S2 complex sequential therapy for superficial transitional carcinoma of urinary bladder. Methods: A prospective, randomized parallel two lines of treatment groups. Seventy-three patients were evaluated after transurethral resection of superficial bladder cancer with median follow-up of 26 months. In group A, 37 patients received intravesical mitomycin C 30mg on day1 weekly for 6 weak and monthly for 12 month, while group B (36 patient) received in addition to mitomycin C, intravesical S2 complex 3ml on day 2. Statistical analysis performed by Kaplan-Meier methods. Result: After follow-up of 26 months, 46% of patient given mitomycin C were disease free compared to 70% for that of group B patient who received mitomycin C and S2 complex, with no significant difference in incidence of the adverse effects. Conclusion: The results show that intensive intravesical instillation of sequential mitomycin C and S2 complex; were highly effective in eradication and/or prophylaxis of superficial transitional bladder cancer.Key ward: Transurethral resection; bacillus Calmitte-Guerin; complete response; mitomycin C, carcinoma in situ

خلفية الدراسة: يأتي سرطان المثانة بالمرتبة الثالثة في الذكور و بالمرتبة العاشرة في الأناث في الولايات المتحدة الأمريكية. في احايين كثيرة بعد استأصاله تستعمل علاجات كيمياوية في غسل المثانة. هدف الدراسة: هو مقارنة برنامجين لمدة سنتين لدراسة التأثير و الفعالية و السمية لعلاج غسل المثانة بعقار مايتومايسين سي مقابل من علاج مايتومايسين سي و مركب س2 تعاقبيا لسرطان المثانة السطحي.طريقة العمل: دراسة عشوائية مستقبلية لمجموعتين من المرضى المصابين بسرطان المثانة السطحي (73مريضأ) بعد الاستئصال بناظور المثانة عبر الاحليل مع متابعتهم لمدة 26 شهرا. المجموعة الاولى (أ) ضمت 37 مريضأ استلموا علاج مايثومايسين سي (غسل المثانة) 30 ملغ في اليوم الاول/ اسبوعيأ لمدة 6 اسابيع و شهريأ لمدة 12 شهرأ زائد المرضى في المجموعة (ب) (36مريض) اضيف لعلاجهم مركب س2 3ملم في اليوم الثاني (غسل المثانة). التحليل الاحصائي صمم بواسطة طريقة كابلان-ماير.النتائج: بعد متابعة لمدة 26 شهرا، 46% من المرضى في المجموعة (أ) كانوا خالين من المرض مقارنة مع 70% للمرضى في المجموعة (ب) فضلا عن ان التاثيرات الجانبية كانت متقاربة.الاستنتاج: النتائج بينت ان علاج غسل المثانة بعقار مايثومايسين سي مع مركب س2 تعاقبيأ كانت فعالا جدأ في انهاء و/او الوقاية من سرطان المثانة السطحي.مفتاح الكلمات: مايتومايسين سي , س2 ,غسل المثانة , سرطان المثانة السطحي


Article
Study of Assessment of the complications for Patients Associated with Transurethral resection of benign prostate Hyperplasia (Turp)

Author: Prof. Dr. Nathera Hussein Alwan Al – suffer Institute of Medical Technology
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467(print) 27068536(online) Year: 2013 Volume: 19 Issue: 77 Pages: 1-15
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractObjective: To assess the complications for patients associated with TURP, and Identify the relationship between the complications with some demographic variable , post operative data , and past history of the patient with TURP.Methodology: A descriptive study was conducted on (78) patients with TURP, who were admitted in the urological floor and out patient urological clinics, was selected out of four Teaching Hospitals in Baghdad city The study was carried out during the period of 1st of June 2007 to the 1st of November 2008. The questionnaire consisted of (2) a major part, The first part is concerned with socio-demographic characteristics of these patients. The second part is concerned with post operative data and complications characteristics of these patients. Data were collected through the use of the questionnaire; the data collection was carried out during the period of 7th of October 2007 to the 30th of May 2008. Data were analyzed through the application of the descriptive and the inferential statistical data analysis approach.Result: The findings of the study proved that, the socio – demographic characteristics of the TURP patients were (age, occupation status, education level, residential area, alcohol drinking, and smoking, had a significant difference effect . also the findings of the study proved that, the post operative data(duration of catheter , duration of irrigation , irrigation volume, and hospital stay duration), and past history of the patient had a significant difference effect for the complications post TURP.Recommendation: The study recommended that, an education oriental program can be designed, constructed and a administered to patients with TURP surgery, and their family through which health and life related issues can be presented.Key wards: patient post TURP Surgery.

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