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Article
Cardiac Troponins as Prognostic Markers in Acute Heart Failure

Author: Muataz Fawzi Hussein
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 214-220
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Cardiac troponins provide diagnostic and prognostic information in acute coronary syndromes, but their role in acute decompensated heart failure is unclear.OBJECTIVE:Describe the association between elevated cardiac troponin levels and adverse events in patients hospitalized with acute decompensated heart failure.METHODS:Troponin was measured at the time of admission in 340 patients who were hospitalized to Baghdad Teaching Hospital for acute decompensated heart failure between October 2007 and October 2008. A positive troponin test was defined as a cardiac troponin I level of 0.5 ng/mL or higher.RESULTS:Overall, 30 patients (8.8%) were positive for troponin. Patients who were positive for troponin had lower systolic blood pressure on admission [138±30 vs. 144±30 mmHg, P value 0.01], a lower left ventricular ejection fraction [mean 33±15 % vs. 38±16%, P value 0.002] and higher in-hospital mortality [3 patients (10%) vs 8 patients (2.58%), P value 0.001] than those who were negative for troponin. The adjusted odds ratio for death in the group of patients with a positive troponin test was 2.45 (95% confidence interval [CI], 2.14 to 2.79; P<0.001) by the Wald test).CONCLUSION:In patients with acute decompensated heart failure, a positive cardiac troponin test is associated with higher in-hospital mortality, independently of other predictive variables


Article
The relation between ECG changes and troponin test in patients with non ST segment elevation acute coronary syndrome
العلاقة بين رسم القلب الكهربائي وفحص التروبونين I في مرضى المتلازمة التاجية الحادة غير المصاحبة لإرتفاع قطعة ST

Author: Arwa M. Fuzi Al-Sarraf اروى محمود فوزي الصراف
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2013 Volume: 39 Issue: 1 Pages: 12-18
Publisher: Mosul University جامعة الموصل

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Abstract

ABSTRACTObjectives: This article focuses on unstable angina and non ST segment elevation myocardial infarction. The objectives are to clarify different ECG pattern, to correlate it with troponin results, and to evaluate the effects of risk factors. Methods: Seventy patients with clinical diagnosis of acute coronary syndrome were collected from coronary care unit in Ibn Sina Teaching Hospital in Mosul, 20 patients with ST segment elevation were excluded, and ECG changes were evaluated. Forty five patients had troponin I test, and the results were compared to their ECG changes. The risk factors and their numbers were studied. Data statistically analyzed using Z- 2 proportion and Chi-square tests. Results: Fifty patients with a mean age 57 year (SD 13.2), including 26 males and 24 females, show (in order of frequency): ST depression (44%), non-specific ECG (24%), T wave inversion (22%), and BBB (10%). Fifteen (33%) had positive troponin test, most of them were males (80%), showed significant association with T wave inversion (p value= 0.05). Specific ECG changes were associated with male gender, diabetes mellitus, hypertension, and old age (p value<0.03). Troponin positivity was associated with male sex (p value=0.003). Male gender and smoking were associated with positive troponin in significant ECG group (p value<0.04). All patients with positive troponin had at least two risk factors (p value=0.002).Conclusion: ST segment depression was the most common ECG changes in non ST elevation acute coronary syndrome, but T wave inversion was more significantly associated with troponin positivity, which differs from previous studies. Male gender was the most critical risk factor; this was consistent with previous studies. Number of risk factor has important effect on ECG and troponin results.

الخلاصةالأهداف: هذه الدراسة تركز على النوبة القلبية غيرالمستقرة، وإحتشاء عضلة القلب غير المصاحب لإرتفاع قطعة ST . الأهداف هي توضيح أنماط رسم القلب الكهربائي، إختبار إيجابية فحص تروبونين I ، وتقييم عواملِ الخطورة.الطريقة: سبعون مريضا شخصوا سريريا بالمتلازمة التاجية الحادة جمعوا من وحدة العناية القلبية في مستشفى ابن سينا التعليمي في الموصل، بعد إستثناء 20 حالة مصاحبة لإرتفاع قطعةST ، تم دراسة أنماط تغييرات رسم القلب لهؤلاء المرضى. وأجري إختبار التروبونين لخمسة وأربعون مريضا منهم، وقورنت نتائج إختبار التروبونين لديهم مع تغييرات رسم القلب الكهربائي. درست عوامل الخطورة وعددها وتأثيرها على أنماط رسم القلب الكهربائي ونتائج إختبار التروبونين. حللت نتائج هذه البيانات إحصائيا بإستخدام إختباري كاي وZ.النَتائِج: تم تشخيص خمسين مريضا بالمتلازمة التاجية الحادة غير المصاحبة لإرتفاع قطعة .STمتوسط أعمارهم 57 سنة: (26 ذكرا و 24 أنثى). أظهر رسم القلب الكهربائي لديهم التغييرات الآتية (من الأكثر الى الأقل شيوعا) : إنخفاض فطعة ST (44%)، تغييرات غير محددة في رسم الفلب (24% (، إنعكاس موجة T (22% (وحصرالحزيمة BBB ) 10%.( كان إختبار تروبونين إيجابي لدى خمسة عشر مريضا (33%) ، ومعظمهم كانوا ذكورا (80%)، وأظهروا علاقة إحصائية مهمة مع إنعكاس موجة .Tإرتبط وجود تغييرات مهمة في رسم القلب الكهربائي بالعوامل التالية: الجنس الذكر، داء السكري، إرتفاع ضغط الدم، والشيخوخة. فيما إرتبطت إيجابية اختبار التروبونين بالجنس الذكر. كان فحص التروبونين إيجابيا في المجموعة التي أظهرت تغييرات مهمة في رسم القلب في الذكور والمدخنون. كل المرضى الذين أظهروا فحص تروبونين إيجابي كان لديهم عاملي خطورة على الأقل.الخاتمة: إنخفاض القطعة ST كان التغير الأكثر شيوعاً في رسم القلب الكهربائي لمرضى المتلازمة التاجية الحادة غير المصاحبة لإرتفاع قطعة ST، لكن إنعكاس موجة Tكان أكثر إرتباطا بإيجابية فحص التروبونين، وهذا معارض لبعض الدراسات السابقة. الجنس الذكر كان عامل الخطورة الأكثر حرجا في المتلازمة التاجية الحادّة، وهذا كان متسقا مع الدراسات السابقة. عدد عوامل الخطورة له تأثير مهم على رسم القلب الكهربائي ونتائج فحص التروبونين.

Keywords

ECG --- troponin --- ACS


Article
The Role of Highly Sensitive Troponin I in Diagnosis and Prognosis of Dilated Cardiomyopathy in Pediatric Age Group

Authors: Eman Hassan Al-Hmairy --- Yasar Mohammed Hassan Al-Shamma --- Muntadhar Yahya Al- Muhanna
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 697-705
Publisher: Babylon University جامعة بابل

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Abstract

The aim of this study, is to evaluate the role of highly sensitive serum troponin I in diagnosis and prognosis of children with dilated cardiomyopathy. This study included 48 children with dilated cardiomyopathy with left ventricular dysfunction, that diagnosed clinically by history, clinical examination ,electrocardiography and echocardiography, including 2D-echocardiography, M-mode and Doppler study. Echocardiography regarded as the corner stone in the diagnosis of dilated cardiomyopathy. Those patient were subdivided to 15 children present with acute heart failure (Acute DCM) (8 female and 7 male), and 33 children who are known cases of dilated cardiomyopathy reported in the cardiology out clinic with chronic cardiac dysfunction (18 female and 15 male),both groups followed for one year with regular clinical, laboratory and echocardiographic evaluation during treatment coarse for cardiac dysfunction , another 48 control healthy child with same age groups involved in the study (25 female and 23male), the age of both patient and control groups ranging from 1month- 12 years. All patient had cardiac dysfunction at the time of attendance . We found that most patient with Dilated cardiomyopathy with acute left ventricular dysfunction had high serum level of highly sensitive troponin I at the time of presentation. Those patients with chronic Dilated , usually had serum troponin above the detectable limit and significantly more than control group. During follow up all patient show to decrease their serum troponin I level with improvement of their cardiac function till reaching normal or nearly normal level if Left ventricular function improved toward normal value, while those remain with left ventricular dysfunction for longer period despite treatment shown to have higher troponin level. This negative relationship between highly sensitive troponin I indicates that the highly sensitive troponin I is important for both diagnosis and prognosis of patient with dilated cardiomyopathy.


Article
A study of effect of carvedilol on serum creatine kinase- MB and troponin I levels in doxorubicin treated females with breast cancer

Author: Sameer Hassan Abboud Al-Rekabi, D.M
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2012 Volume: 15 Issue: 1 Pages: 314-319
Publisher: University of Kufa جامعة الكوفة

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Background: Doxorubicin based regimen is the most common treatment of breast cancer which is highly complicated by cardiotoxicity.Aim: To clarify the possible effects of carvedilol on serum CK-MB and Troponin I in doxorubicin based regimen in females with breast cancer.Patients and Methods: A total of 16 females with breast cancer were included in this study. The patients were randomized into 2 groups , 8 patients each. Group I included patients were treated with doxorubicin based regimen for 6 cycles with 21 day apart. Group II included patients were received doxorubicin based regimen with carvedilol 3.125 mg , orally , twice daily for 5 days , for 6 cycles. Serum CK-MB and Troponin I were measured at zero time and 3 days after 2nd, 4th and 6th cycles in both groups.Results: The following results were obtained:1- Treatment with doxorubicin based regimen caused highly significant elevation in serum CK-MB and Troponin levels after 2nd, 4th and 6th cycles in comparison to baseline readings (P < 0.01).2- Combined CAF + Carvedilol 3.125 mg orally twice daily for 5 days caused highly significant decrement in serum CK-MB and Troponin I levels compared with that of doxorubicin based regimen group (P < 0.01).Conclusion: From the present study , we can conclude that Carvedilol causes highly significant decrease in serum CK-MB and Troponin I levels in doxorubicin treated patients.

الخلفية: يعتبر النظام العلاجي المعتمد على الدوكسوروبوسين من أكثر العلاجات استخداما لعلاج سرطان الثدي والذي قد يتسبب بتسمم القلب.الهدف: هدف الدراسة هو لتوضيح أمكانية تأثير عقار الكارفيديلول على أنزيم CK-MB وبروتين Troponin I لدى النساء المصابات بسرطان الثدي اللواتي يستخدمن عقار الدوكسوروبوسين.المرضى وطريقة العمل: شاركت 16 امرأة تعاني من سرطان الثدي في هذه الدراسة. وزعت المريضات عشوائيا إلى مجموعتين, كل مجموعة تحوي على 8 مريضات. تضمنت المجموعة الأولى مريضات تم علاجهن بعقار الدوكسوروبيسين لست دورات مفصولة بواحد وعشرين يوما, أما المجموعة الثانية فقد احتوت على مريضات تم علاجهن بعقاري الدوكسوروبيسين + الكارفيديلول 3,125 ملغم عن طريق الفم , مرتان يوميا لمدة 5 أيام بعد كل جرعة من الدوكسوروبوسين لست دورات. تم قياس مستوى أنزيم CK-MBو بروتينI Troponin في مصل الدم لكل مريضة قبل (وقت الصفر) وبعد 3 أيام من وقت الجرعة الثانية والرابعة و السادسة.النتائج: تم الحصول على النتائج التالية:1- سبب النظام العلاجي المعتمد على الدوكسوروبوسين زيادة معنوية عالية في مستوى أنزيم CK-MB و بروتين I Troponinبعد الجرعة الثانية والرابعة والساسة مقارنة مع القراءات الأولية.P< 0.01 2- سبب استخدام الكارفيديلول مع الدوكسوروبوسين نقصان معنوي عالي في مستوى أنزيم CK-MB وبروتين Troponin I مقارنة مع استخدام الدوكسوروبوسين فقط. P < 0.01 الاستنتاج: من هذه الدراسة , يمكن أن نستنتج بان عقار الكارفيديلول يسبب نقصان معنوي عالي في مستوى أنزيم CK-MB وبروتين Troponin Iلدى المريضات المصابات بسرطان الثدي اللواتي يستخدمن نظام علاجي المعتمد على الدوكسوروبوسين.


Article
The Impact of Long Term Prognosis of Troponine in High Risk Unstable Angina

Author: Haitham Noaman Al-Koubaisy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 3 Pages: 306-309
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND : To evaluate the long term prognosis (6 months of follow up) regarding mortality , acute myocardial infarction and coronary angiography results in patients with troponin positive or negative in high risk unstable angina pectoris .METHODS : All patients included in this study were adults, 73 patients, 52(71.24%) male versus 21(28.76%) female of different ages . All had clinical features of ischemic chest pain of high risk unstable angina. They attended private clinic in HIT city, Anbar Governorate ( West of Iraq ) during the period January 2010 – December 2012. All had planner ST-segment depression in electrocardiography (ECG) according to concordant ECG leads other ECG findings of T- wave inversion or ST- elevation myocardial infarction were excluded, measurement of serum troponin test was done for all patients. All patients included in the study were admitted to coronary care unit (CCU) and received full treatment including heparin and discharged from hospital when they were clinically stable. Coronary angiography was done for all patients and followed up for 6 months.RESULTS : From all patients included in this study 27(36.98 % ) were troponin positive unstable angina, 3 (11.12%) patients of them were died and 24 (88.88 % ) patients of them survived. Their coronary angiography were sever type in 11(40.74 %) patients and they did coronary artery bypass surgery(CABG) and 13(48.14 % ) patients had multiple lesions in more than one vessels and need more than one balloon and stent(Percutaneous trans luminal coronary angioplasty PTCA) .While those whom troponin negative unstable angina were 46( 63.02 %) patients all were survived, only 5 (10.86 %) of them need coronary artery bypass surgery, 27 (58.69 %) patients need single or multiple stents , 4(11.5 %) patients had non critical coronary artery lesion only for medical treatment and the remaining 11 ( 41.81 %) patients were had normal coronary angiography .CONCLUSION : Troponin positive high risk unstable angina carry poor prognosis where has 3 times more mortality risk and more likely to be in need for surgery and difficult stenting and may not be able to be treated surgically or by stenting but medically without intervention than negative troponin high risk unstable angina .


Article
Troponin Positive Acute Coronary Syndrome with and without Significant Stenosis on Coronary Angiography

Authors: Mohammed Hilal AL-Ali --- Hassan A. Farhan
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 2 Pages: 237-243
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND: Occasionally, coronary arteries without significant stenosis are observed during invasive treatment of acute coronary syndrome (ACS). OBJECTIVE: The aim was to study the frequency and to determine the most predictive factors of Troponin positive ACS without significant Stenosis on angiography.METHODS:The study involved one hundred twenty four patients admitted with Troponin positive ACS who underwent cardiac catheterization during hospitalization. The primary end-point was the estimation of coronary arteries without significant stenosis, and the secondary end-point was analysis of the most predisposing factors. In evaluating the primary end-point, the patients were divided into two groups according to the presence of ST elevation myocardial infarction (STEMI) or not. Also the patient who has no significant coronary artery Stenosis (< 50%) was subdivided to two groups:a- Myocardial Infarction with No critical lesion in Coronary angiogram (MINC)b-Normal coronary angiogramRESULTS: Overall, 20 patients (16%) had coronary arteries without significant lesions, from which 8 patients (6.4%) had MINC and 12 patients (9.6%) had normal coronary angiogram. The predictors were: female sex (P=0.008), age <45 years (P=0.001), and the absence of: diabetes (P=<0.001), hypertension (P=0.005) and absence of ST-segment elevation (P=0.001). Furthermore absence of regional wall motion abnormality (RWMA) is considered as another predictors for non-significant coronary artery lesion (P=0.008). Also the angiographic analysis of all lesions revealed that single vessels CAD are the commonest finding in Group I patients (P= 0.02). We further analyzed a suspicious angiographic lesions by using QCA {18 lesions (14.5%)} and FFR {6 lesions (4.8%)} technique.CONCLUSION: Overall, patients with Troponin positive ACS had non- significant coronary artery Stenosis on angiography, and female sex, age <45 years and the absence of diabetes, hypertension, ST- segment elevation or RWMA were all associated with coronary angiography showing no significant stenosis.


Article
Quercetin role in moderating the side effects of chemical drug Doxorubicin in Troponin level and some cardiac enzymes in local male rabbits
دور مادة كوركتين في تلطيف الآثار الجانبية للعقار الكيماوي دوكسوروبسين في مستوى تروبونين وبعض الإنزيمات القلبية في ذكور الأرانب المحلية

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Abstract

The study aim to detect the treatment effect of Quercetin in mitigation the toxic effect of Doxorubicin drug in heart function in 32 local male rabbits divided randomly into four equal groups treated for 28 days as follow; Control group given daily distilled water orally and injected with 4ml normal saline weekly. First treatment group given orally 10mg/kg Quercetin daily and injected with 4ml normal saline weekly. Second treatment group injected with 4mg/kg doxorubicin weekly and given daily distilled water orally. The third treatment group given 10mg/kg Quercetin daily and injected with 4mg/kg doxorubicin weekly. Results showed a significant (P<0.05) increase of Troponin, CK-MB and LDH levels in second group treated with doxorubicin only compared with normal levels of these parameters in control group, conversely there is positive interrelating non significant (P>0.05) among control group and other groups which treated with Quercetin, first as well as third groups in which Quercetin reduces all parameters significantly (P<0.05). In conclusion; The Quercetin has important role in reduced negative side effects of Doxorubicin in heart function.

تهدف الدراسة الى تحديد التأثير العلاجي لمادة Quercetin في تلطيف التأثيرات السمية لعقار Doxorubicin في وظيفة القلب. أجريت التجربة في البيت الحيواني التابع لكلية التربية/جامعة القادسية واستمرت لمدة 28 يوما استخدم فيها 32 من ذكور الأرانب المحلية وزعت عشوائيا إلى أربعة مجاميع متساوية تم معاملتها على النحو التالي: مجموعة السيطرة جرعت بالماء المقطر يوميا وحقنت أسبوعيا 4ml من المحلول الفسيولوجي ، مجموعة المعاملة الأولى جرعت بمادة Quercetin بتركيز 10mg/kg يوميا وحقنت أسبوعيا 4ml من المحلول الفسيولوجي ، مجموعة المعاملة الثانية حقنت الحيوانات أسبوعيا بعقار Doxorubicin بتركيز 4mg/kg وكان الحقن متزامن مع تجريع الحيوانات 4ml من الماء المقطر يوميا ، مجموعة المعاملة الثالثة جرعت الحيوانات بمادة Quercetin بتركيز 10mg/kg يوميا مصحوبا بحقن الحيوانات بعقار Doxorubicin بتركيز 4mg/kg أسبوعيا. أظهرت نتائج التحليل الإحصائي حصول ارتفاع معنوي (P<0.05) في مستوى Troponin, CK-MB, LDH في مجموعة المعاملة الثانية وذلك عند مقارنة نتائج هذه المجموعة مع المستوى الطبيعي لهذه المعايير الذي ظهر في نتائج مجموعة السيطرة ، بالمقابل لوحظ وجود تقارب ايجابي واضح وصل إلى درجة انعدام المعنوية (P>0.05) في مستوى هذه المعايير ما بين مجموعة السيطرة وبين المجاميع التي تم معاملتها بالمادة النباتية الفعالة Quercetin وهي مجموعة المعاملة الأولى وكذلك مجموعة المعاملة الثالثة ففي المجموعة الثالثة خفضت مادة Quercetin مستوى المعايير المدروسة معنويا (P<0.05) مقارنة بمجموعة المعاملة الثانية ، كما اظهر الفحص النسجي للمقاطع المأخوذة من حيوانات المعاملة الثانية وجود تحلل واضح في الألياف العضلية القلبية مع وجود تنخر شديد في الألياف وغياب واضح للتخطيط العرضي في معظم مناطق النسيج فضلا عن وجود تفجج وتباعد شديد بين الألياف العضلية القلبية في حين لم تشاهد معظم هذه التأثيرات السلبية في مجموعة المعاملة الثالثة رغم كون عقار Doxorubicin جزء من معاملتها. نستنتج مما تقدم أن مادةQuercetin لها دور مهم في تقليل التأثيرات السلبية لعقار Doxorubicin في وظيفة القلب وتقليل الأضرار النسجية السلبية للعقار في عضلة القلب.


Article
The Association Between Adiponectin with Lipid Profile and Troponin in Acute Myocardial Infarction Patients

Author: Ammal Esmaeel Ibrahim
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 50-56
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Adiponectin is thought to be exclusively synthesized by adipocytes; however, a recent suggestionstated that adiponectin is also synthesized and secreted by human cardiomyocytes. Adipose tissueis increasingly recognized as a key regulator of energy balance, playing an active role in lipidstorage and buffering, and synthesizing and secreting a wide range of endocrine products that maybe directly involved in the pathogenesis of the complications associated with obesity. So obesityconsider the major independent risk factor for atherosclerotic cardiovascular disease AcuteMyocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing someheart cells to die. Insulin is a very important hormone as it regulates the level of glucose, in theblood. Troponin is a complex of three regulatory proteins that is integral to muscle contraction inskeletal and cardiac muscle.OBJECTIVE:To monitor adiponectin level and its effect on lipid profile and Troponin levels in AcuteMyocardial infarction patients.SUBJECTS AND METHODS:The study included 50 patients with Acute Myocardial infarction and forty healthy subject ascontrol group. This study designed to measure adiponectin, lipid profile and troponin levels.RESULTS:Levels of adiponectin, cholesterol, LDL-C and Troponin were significantly elevated with(p<0.001), while HDL-C was significantly lower with (p<0.001), There was negative correlationbetween adiponectin with , cholesterol LDL-C, triglyceride and VLDL, and there was positivecorrelation between adiponectin with HDL in acute myocardial infarction.CONCLUSION:The significant increase in adiponectin in AMI may be related to inflammation. From the relationof adiponectin with lipid profile, adiponectin can increase level of HDL and decrease level oftriglyceride so this suggested that adiponection have anti-atherosclerosis properties


Article
Troponin I and Creatine Kinase (MB) as Biochemical Markers in Acute Myocardial Infarction

Author: Salman A Ahmed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 82-86
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Ischemic heart disease is the leading cause of death among adults. Broad based studies that include allED patients who received an ECG for the evaluation of chest pain syndromes found that 5% of thesepatients were ultimately diagnosed with acute myocardial infarction (AMI) and an additional 10% hadnon-AMI acute coronary syndromes (ACS). Thus, 85% of patients have non-ACS causes for theirsymptoms.OBJECTIVE:To study the relation between the level of cardiac troponin I and creatine kinase (MB) in AcuteMyocardial infarction.SUBJECT AND METHOD:The present study was designed to investigate changes in serum cardiac biomarkers in patients withacute myocardial infarction. The present study consists of 61 patients who were admitted to the hospitalwith acute myocardial infarction. Serum levels of cardiac troponin I (cTnI) and creatine kinase (MB)were determined on day 1 (within24 hours) and the 3rd day after acute myocardial infarction. Serumcardiac biomarkers were compared between day 1 of acute myocardial infarction and the 3rd day afterthe acute myocardial infarction with healthy subjects (control group). All measurements were takenthrough September 2009 to April 2010 in department of medical and molecular biotechnology/Biotechnology Research Center/ Al-Nahrain university and Ibn Al-Nafees Hospital Department ofClinical Chemistry and Coronary Care Unit. Cardiac troponin I (cTnI) and CK-MB were measured byusing microtitre plate ELISA method, absorbance is measured spectrophotometrically at 450 nm.Levels of serum cTnI and CK-MB for smoker patients who suffered from MI and otherdiseases(diabetes mellitus, and hypertension) (group 4) higher than levels for patients who complainedfrom MI in addition to other diseases(group2), group 2 higher than levels for smoker patients whosuffered from MI (group 3) and group 3 higher than levels for patients who complained from only MI(group 1).RESULTS:Results showed significant (p<0.01) decreases observed for the levels of cTnI in group 4 with group 1and group 2 with group 1, and significant (p<0.05) decreases in group 4 with group 3. Significant(p<0.05) decreases were observed for the levels of CK-MB in group 4 with group 1.CONCLUSION:Myocardial infarction patients with diabetes mellitus , hypertension and smoking suffer increase levelsof cTnI and CK-MB. This proved that cardiac risk factors increase risk for heart injury. However, suchresults must be considered during the evaluation of the results of cardiac biomarker in patients of MI .


Article
Level of Resistin in Acute Myocardial Infarction Patients and its Relation to Lipid profile and Cardic Troponin I

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 430-435
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Inflammatory responses are involved in the initiation and progression of atherosclerotic plaques. Myocardial Infarction (MI) is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process. Resistin is a cysteine-rich polypeptide that is expressed at relatively lower levels in human adipocytes but higher levels in macrophages. Troponin is found in cardiac muscle and used for diagnosis of AMI.OBJECTIVE:To investigate the level of resistin and its effect on lipid profile and Troponin I levels in acute myocardial infarction patients.SUBJECT AND METHODS:The study included 50 patients with AMI and forty healthy subjects as control group. In this study resistin , lipid profile and Troponin I were measured.RESULTS:The levels of resistin, cholesterol, LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between resistin with cholesterol, LDL-C, triglyceride and VLDL, while there was negative correlation between resistin with HDL in acute myocardial infarction.CONCLUSION:There was a significant increase in resistin level, in acute myocardial infarction patients and this increase may be related to inflammation. Resistin negatively correlated with HDL and positively correlated with triglyceride and LDL this relationship makes us consider this hormone as possible atherosclerotic factor

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