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Article
STUDY THE EFFECT OF PROANTHOCYANIDIN AND RANITIDINE ON HAEMATOLOGY AND BIOCHEMICAL PARAMETERS IN ADULT FEMALE RABBITS WITH GASTRIC ULCERATION INDUCED BY INDOMETHACIN
دراسة تأثير بروانثوسياندين و الرانتدين على المعايير الدمويه والكيموحيويه في اناث الارانب البالغة المستحدثه القرحه بواسطه الاندوميثاسين

Author: Abrar S. Abdul -Razak* Muna H. AL-Saeed** Eman A. AL-Masoudi
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2016 Volume: 15 Issue: 1 Pages: 132-160
Publisher: Basrah University جامعة البصرة

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The study was conducted in Collage of Veterinary Medicine Basrah University,to evaluate the effect of proanthocyanidin and ranitidin on gastric ulcer, haematological and biochemical parameters changes by using female rabbits with acute gastric lesions induced by indomethacin.The study done on (30)adult female rabbits, their weight ranged between (1500-2000.0mg); divided into five groups, each group consist of six rabbits as the following: Group1:- healthy (negative control group) administrated normal saline (0.9 of normal saline) for 10 days; Group 2:-given indomethacin 75mgkg B.W. for two days(positive control group); Group 3:- at first given indomethacin 75mgkg B.W. for two days, then treated with proanthocyanidin(PA) 100mgkg B.W. for 10 days; Group 4, initially given indomethacin 75mgkg for two days, then treated with proanthocyanidin(PA) 200mgkg for 10 days; Group 5, given indomethacin 75mgkg for two days, then treated with ranitidin 50mgkg for10 days.The results showed that proanthocyanidin(PA) and ranitidin caused significant reduction (P≤0.05) in gastric volume, ulcer area, serum MDA, gastric tissue MDA while significant increase (P≤0.05) in mucin and gastric pH. It also revealed significant decrease (P≤0.05) in glucose concentration in rabbits treated with proanthocyanidin compared to positive control group while showedno-significant change in glucose concentration in rabbits treated with ranitidine compared with positive control group. It also, showed significant increase (P≤0.05) in Red Blood Cell(RBC),Hemoglobin(Hb) andMean Corpuscle hemoglobin concentration(MCHC) in rabbit treated with proanthocyanidin or ranitidin, while there was significant decrease (P≤0.05) in Mean Corpuscle Volume(MCV) in rabbits treated with proanthocyanidin in dose of 100mgkgand ranitidine in a dose of 50mg/kg with non-significant change of MCV in female rabbits with gastric ulceration treated with proanthocyanidin at dose 200 compared with positive control group.It showed non-significant changes in White Blood Cell (WBC) of female rabbits with gastric ulceration treated with proanthocyanidin compared with positive and negative control groups, while the results showed significant decrease (P≤0.05) in WBC of female rabbits with gastric ulceration treated with ranitidine group compared with positive and negative control groups and the other groups. The study revealed significant decrease (P≤0.05) in total cholesterol, triglyceride, Low Density Lipoprotein(LDL) and very Low Density Lipoprotein(VLDL) of female rabbits with gastric ulceration treated with proanthocyanidin and ranitidine group compared with positive control group while it showed significant increase (P≤0.05) in High Density Lipoprotein (HDL) in rabbits treated with proanthocyanidin and ranitidine group compared with positive control group. It is concluded that proanthocyanidin extract of the grape seeds(Vitis vinifera)displayed good antiulcer activity, hypoglycemia effect, amelioration of heamatological parameters and improve dyslipidemia corroborating the folk use of Vitis vinifera preparations, and contributing for its pharmacological validation.


Article
Vanillin soothing effect in treating certain oral disease entities

Authors: Tahani A AL-SANDOOK --- Bassman A KHALIL --- Nahla O TAWFIK
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2001 Volume: 1 Issue: 2 Pages: 143-147
Publisher: Mosul University جامعة الموصل

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Abstract

Topical application of 2% vanillin in glycerin was found to be effective in relieving pain associated with aphthus ulceration, hypersensitive cementum and ulcerative margin associated with pericoronitis. This analgesic effect of vanillin was explained to its local anesthetic effect


Article
EFFECT OF THE AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON STRESS-ETHANOL INDUCED ACUTE GASTRIC ULCERATION IN RABBITS
تأثير المستخلص المائي لأزهار البابونج على القرحة المعدية المحدثة في الأرانب بواسطة الإجهاد والكحول الاثيلي

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Abstract

ABSTRACTThe anti-ulcer effect of the aqueous extract of Matricaria chamomilla flowers (chamomile extract, CE)had been tested on stress- ethanol induced gastric ulceration in rabbits. The first part of the study was toinduce acute gastric ulceration by stress or stress–ethanol combinations. Stress alone was unable toproduce gastric ulcerations while ulcer was induced in the group of rabbits exposed to stress in thepresence of ethanol (5ml / kg ) with a mean value of ulcer index of 108.3mm ± 29 (n=8). Histopathologicalexamination was done to confirm the effect of stress-ethanol combination on gastric mucosa. The secondpart of the study was performed to investigate the pharmacological effect of various concentrations ofthe aqueous extract of chamomile (1%, 4% and 8%) on gastric ulceration. The extract was given 15minutes before ethanol administration. The results have shown a significant anti ulcer effect ofchamomile extract with mean values of ulcer index of 76. 4mm± 14.2 (P< 0.01); 11mm ± 14.2 (P<0.005)and 53mm±27.9 (P<0.01) for the concentrations 1%, 4% and 8% respectively as compared to the controlvalue of 133.25 mm±46.2 (n=8). It is concluded that the extract of Matricaria chamomilla flowers has antiulcer effect.

تم اختيار التأثير المضاد للقرحة للمستخلص المائي لأزهار نبات البابونج على القرحة المعدية المحدثة في الأرانب بواسطة الإجهاد والكحول الاثيلي المطلق. وكان هدف الجزء الأول من هذه الدراسة هو إحداث القرحة المعدية الحادة بواسطة الإجهاد والكحول معا". وقد أظهرت النتائج إلى إن الإجهاد لوحده غير كاف لإحداث تقرحات وفرط الدم، ولكن هذه التغييرات تحدث في المجموعة المعالجة بالكحول بعد الإجهاد وكان معدل منسب القرحة هو (29+108.3 ملم). وقد اجري الفحص النسيجي الموضعي لتأكد تأثير الكحول والإجهاد على الغشاء المخاطي للمعدة حيث اظهر الفحص وجود تقرحات وموات موضعي واحتقان ووذمة وظهور خلايا التهابية. أما الجزء الثاني من الدراسة فيتضمن دراسة التأثير الدوائي للمستخلص المائي للبابونج وبتراكيز 1% و 4% و 8% على التقرحات المحدثة. وقد تم إعطاء مستخلص البابونج قبل إعطاء الكحول المطلق بــ15 دقيقة. أظهرت النتائج وجود تأثير مضاد للقرحة لمستخلص البابونج بشكل معتد إحصائيا" وكانت قيم المعدلات لمنسب القرحة للتراكيز 1% و 4% هي (76,4 ملم+ 12,2) (P<0.01) و (11ملم+14,2) (P<0.005) و (53 ملم + 27.9) (P<0.01) على التوالي عند المقارنة مع المجموعة الضابطة حيث كان منسب القرحة هو (133,25 ملم + 46,2). وتخلص الدراسة إلى أن المستخلص المائي لأزهار البابونج له تأثير مضاد لقرحة المعدة المحدثة في الأرانب.


Article
The Roleof Sodium Lauryl Sulfate as aCausative Agent of RecurrentAphthous Ulceration
تأثير مادة صوديوم لوريل سولفيت كمادة مسببة لزيادة ظهور حالات التقرح في الفم

Author: Karar Abdulzahra Mahdi
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2016 Volume: 6 Issue: 1 Pages: 172-175
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: Sodium lauryl sulfate (SLS) is a detergent that has been used as the major surfactant in most dentifricesand could affect the barrier function of oral mucosa causing enhanced penetration of exogenous antigens.Objective: The aim of this clinical trial was to compare the effects of an SLS-free dentifrice and an SLS-containing dentifrice in patients suffering from recurrent aphthous ulcers .Method: This study was achieved in private clinic from 10/1/2015 to 1/6/2015,in this study, 33 volunteers (20 women, 13 men; mean age, 22 years: range, 15-35 years) were included, all have a history of recurrent aphthous ulceration. Two different dentifrices were used in the study. One contained SLS, and the other was SLS free. The patients were randomly allocated to one of the test toothpastes for 8 weeks, Then the patients changed to the other toothpaste for another 8 weeks period.The patients were asked to record on 100 mm visual analogue scales (VAS) the sorenessarising from the ulcerated area, as well as the total number of ulcers, t-test was used to determine the statistical difference. Results: The number of ulcers and baseline soreness scores were significantly less in the group of patients using SLS free tooth pasteConclusions: This study concluded that using SLS free toothbaste can decrease the number of recurrent aphthous ulcers and the soreness that result from these ulcers regardless of the gender of the patients.Recommendations: It was recommended to enhance the use of SLS free tooth baste to minimize the number of recurrent aphthous ulcers and the soreness

خلفية البحث : صوديوم لوريل سلفات هو منظف يعتبر كعامل رئيسي لتقليل الشد السطحي، ويستخدم في معاجين الأسنان، ومن الممكن أن يؤثر في وضيفة العزل الموجودة في الغشاء المخاطي الفموي مما يؤدي الى زيادة دخول العوامل الخارجية.الهدف : إن هدف هذه الدراسة هو لمقارنة تأثير معجون الأسنان المحتوي على صوديوم لوريل سلفات مع معجون الأسنان الخالي منه على المرضى الذين يعانون من التقرحات الفموية المتكررة.المنهجية : أجريت هذه الدراسة في العيادة الخاصة للمدة من 10/1/2015 إلى 1/6/2015، اشترك في هذه الدراسة 33 متطوعاً (20 انثى , 13 ذكراً , متوسط العمر :22 عام وتتراوح اعمارهم بين 15_35 سنة) .جميع المشتركين يعانون من تقرحات فموية متكررة. تم اختبار نوعين من معاجين الاسنان الاول يحتوي على مادة صوديوم لوريل سلفات والأخر لا يحتوي على هذه المادة . المشاركون تم توزيعهم بشكل عشوائي على كلا المعجونين ليستخدموه لمدة 8 اسابيع ومن ثم تم تغيير نوع المعجون الى 8 أسابيع أخرى. تم الطلب من المشتركين لتسجيل شدة الألم المصاحب للتقرحات على مقياس (vas) والذي يتكون من 100 تدريج حسب شدة الألم .بالإضافة إلى ذلك طلب منهم تسجيل عدد التقرحات التي تظهر في الفم، تم استعمال اختبار t لتحديد الفروق الإحصائية .النتائج : عدد التقرحات وشدة الالم المصاحب لها كان أكثر في المجموعة التي استخدمت معجون الأسنان المحتوي على صوديوم لوريل سلفات.الاستنتاج : نستنتج من هذه الدراسة ان استخدام معجون الأسنان الذي لا يحتوي على مادة صوديوم لوريل سلفات من الممكن أن يقلل من نسبة حدوث حالات التقرح الفموي المتكررة.التوصيات : أوصت الراسة بضرورة تعزيز استخدام معجون الأسنان الذي لا يحتوي على مادة صوديوم لوريل سلفات وذلك للتقليل من نسبة حدوث حالات التقرح الفموي المتكررة.


Article
Study of Pseudomonas Areuginosa Proteases Enzymes in Corneal Ulceration by Using Real - Time PCR

Authors: Aida Hussain Al – Saa'edi --- Munera Chaloob. Al - Abaadi --- Jassim Mohammed Karhoot --- Faiz Al- Sakarchi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 2 Pages: 281-287
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Pseudomonas aeruginosa (P. aeruginosa) is the most frequently isolated bacteria in clinical cases of ulcerative keratitis. P. aeruginosa produces several proteases and toxins, the best characterized being exotoxin, elastase, alkaline protease and IV. These are all important factors in the establishment of bacterial infection and the amount of damage caused by the infection to the cornea.OBJECTIVE:The aim of the present study was to study the role of P. aeruginosa proteases ( elastase ( LasB) , LasA, Alkaline protease, and protease IV ) in corneal ulceration by using Real - time PCR.METHODS : One hundred - twenty clinical samples (corneal scraping) were collected from patients suspected with bacterial keratitis presenting to Ibn –Alhaytham Teaching Hospital from May 2013 until November 2013. Methods for isolation and identifying P. aeruginosa based upon culture coupled with biochemical tests and confirmed by new technique called Vitek 2 compact system. The role of proteases enzymes ( elastase ( LasB), LasA, alkaline protease and protease IV ) of P. aeruginosa in the corneal ulceration was studied by Real – time PCR.RESULTS :Real time aalysis demonstrated that three bacterial isolates of P. aeruginosa were possessed elastase gene (11.5%), one bacterial isolate was harbored LasA gene (3.8%), twenty bacterial isolates were possessed protease IV gene ( 76.9%) , and all bacterial isolates were possessed alkaline protease gene (100%).CONCLUSION: The presence of the alkaline protease and protease IV genes in almost bacterial isolates of P. aeruginosa improved the fact that these enzymes were not only tissue damaging but also very important colonizer agents to cornea.


Article
PARTIAL PURIFICATION AND CHARACTERIZATION OF PROTEASE IV FROM PSEUDOMONAS AERUGINOSA
التنقية الجزئية وتوصيف البروتييز Pseudomonas aeruginosa منIV

Author: رباب عمران
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2007 Volume: 6 Issue: 1 Pages: 94-106
Publisher: Baghdad University جامعة بغداد

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Clinical strain Pseudomonas aeruginosa No.3 was isolated from humancorneal ulceration. The bacterial cells secreted the extracellular protease inliquid culture. The enzyme was partial purified 191 fold from culture filtrate bysequential steps such as salting out with ammonium sulfate precipitation (80%saturation), ion exchange CM- Cellulose Chromatography, and by SephadexG-75 Gel filtration.Characterization study of the partially purified enzyme revealed that theenzyme had an optimum activity at pH 9.5 and the activity was stable in thealkaline pH range (8- 10 )for 30 min. Enzyme activity toward casein increasedwith temperature raise up to 35°C and maximal activity was attained at 45° C.The enzyme was stable at temperature under 30˚C and approximately 90% ofthe activity was abolished by incubation of the enzyme at 60 ° C for 40 min or at80 ° C for one min. Protease IV activity was partially inhibited byphenylmethylsulfonyl fluoride (20%) and Diisopropyl fluorophosphate (75%).EDTA at 50mM caused a 22% inhibition of protease activity, which suggestedthat the enzyme is a serine protease. The reducing agents dithiothreitol (1.0 mM)and 2- mercaptoethanol (150-mM) also demonstrated complete inhibition of theenzyme, which suggests that the enzyme protein containing disulfide bonds couldbe important in maintaining the molecular conformation required for activity.__________________________________________________________

من تقرح قرنية عين الانسان. Pseudomonas aeruginosa No. عزلت السلالة السريرية 3تفرز خلايا البكتريا البروتييز الخارجي الى الوسط السائل. تم تنقية الانزيم جزئيا 191 مرة من راشح المزرعةبعدة خطوات متسلسلة مثل الترسيب بملح كبريتات الامونيوم ( 80 % تشبع) وكروموتوغرافيا التبادلSephadex والترشيح الهلامي بوساطة عمود الهلام (Batch-wise CMC) الايوني بطريقة الوجبة.G-75تم دراسة بعض صفات الانزيم المنقى جزئيا , إذ وجد ان يمتلك فعالية مثلى في الرقم الهيدروجيني10 ) لمدة 30 دقيقة . تزداد - 9.5 وان الانزيم ثابتا في مدى من الرقم الهيدروجيني القاعدي ( 8الفعالية الانزيمية اتجاه الكازين بارتفاع درجات الحرارة اكثر من 35 م وكانت الفعالية العظمى له عند45 م. ويكون الانزيم ثابتا في درجات حرارية ادنى من 30 م ويفقد 90 % من الفعالية بعد حضنه(Protease IV) بدرجة حرارة 60 م لمدة 40 دقيقة او 80 م لمدة دقيقة واحدة. يثبط البروتييز.(%75) Diisopropyl fluorophosphate %20 ) و ) phenylmethylsulfonyl fluoride بوساطة50 ملي مولر) تثبيطا بنسبة 22 % لذلك يعتقد بان الانزيم من نوع بروتييز السيرين. تظهر ) EDTA ويسبب150 ملي مولر ) تثبيطا ) 2- mercaptoethanol 10 ملي مولر) و ) dithiothreitol المواد المختزلةكاملا للفعالية الانزيمية لذلك يعتقد بان بروتين الانريم يحتوي على اصرة ثنائية الكبريت للمحافظة علىالتركيب الفراغي الملائم للفعالية.PDF


Article
The Effects of Topical Ketamine Gel on Saliva and Serum Level of Interlukin-6 in Patients with Recurrent Aphthous Ulceration

Authors: Ghada A. Taqa --- Ahmed A. Mohammad --- Abbas F. AL-Taee
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2015 Volume: 15 Issue: 1 Pages: 387-392
Publisher: Mosul University جامعة الموصل

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Aims: To evaluate the effect of topical application of ketamine gel )0.5%( and gel alone)without ketamine( on salivary and serum level of human interlukin-6)IL-6 (in patient with recurrent aphthous ulceration )RAU( and compare the results with control group having no RAU. Materials and methods: The investigation was carried out on)36( subjects with mean ± SD ages )25.11±6.31(years and different sex )20 males,16 females(. These subjects were divided into three groups. Group1: The study group consisted of )12(patients having minor RAU received topical ketamine gel )0.5%( applied on the lesion. Group2: The placebo group consisted of )12(patients having minor RAU received topical gel alone. Group3: The control group consisted of )12( healthy subjects having no RAU.Peripheral venous blood and saliva samples were collected from all subjects before treatment, and four days after treatment from group1and group2 only, to assess the levels of serum and salivary )IL-6( by Enzyme Linked Immuno Sorbent Assays )ELISA( method. Patients were subjectively assessed for the intensity of pain which was recorded pre and four days post treatment in group1 and 2 by using Verbal Pain Scale )VPS(. Data were analyzed using paired t-test, One way ANOVA and Willcoxon Signed Ranks test. Results: The results showed that the mean of serum IL-6 concentrations were high in the study and placebo groups )18.49±5.4pg/ml( and )18.97± 7,47 pg/ml( respectively before treatment comparing with mean of serum IL-6 concentration of control group )9.63±2.77pg/ml(, and the mean of salivary IL-6 concentrations were high in the study and placebo groups )63.03±47.28pg/ml( and )62.25±45.14pg/ml( respectively before treatment comparing with mean of saliva IL-6 concentration of control group )13.1±5.08pg/ml(.


Article
Spirometric evaluation of gastroesophageal reflux disease (gerd) associated cough and asthma
تقييم وظائف الرئة لمرضى الجزر المعدي المريئي المترافق مع السعال والربو

Authors: Shaimaa A. H. Jassim شيماء عبد الهادي --- Afraa M. AL-Ameen عفراء محمد --- Amjad F. Ahmad امجد فوزي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2014 Volume: 56 Issue: 4 Pages: 422-425
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Gastroesophageal reflux disease can lead to esophageal complications, including esophagitis, ulceration, stricture, hemorrhage, and Barrett's esophagus. However, the spectrum of problems associated with GERD has expanded to extra esophageal sites. Chronic cough and asthma are two clinical problems caused or triggered by GERD. Spirometric changes among GERD associated cough and asthma still a topic of ongoing research.Objectives: This study was designated to evaluate the spirometric picture of GERD associated cough and asthma subjects in relation to different clinical aspects of the disease including body mass index (BMI), disease duration, presence or absence of symptoms as well as endoscopic findings. Subjects and methods: Ninety adult subjects (90) of either sex with a mean age of 40.5±12 year are involved in this study. Fifty five (55) GERD associated cough and asthma subjects served as test group while the remaining (35) served as control group. Each subject underwent spirometry and gastric endoscopy in Pulmonary Function and Endoscopy Units respectively at Ibn-Sina Teaching Hospital /Mosul.Results: Spirometric data of the control group were within the normal predicted range (80-120%) thus excluding the possibility of any asymptomatic obstructive airway disease. Whereas, the measured spirometric parameters (forced vital capacity (FVC), forced expiratory volume in 1 second ratio (FEV1%), peak expiratory flow (PEF), and forced mid expiratory flow(FMF) are significantly reduced in the test group with a clear restrictive pattern among the overweight subjects. In addition, neither the presence nor duration of symptoms affected the spirometric picture of the GERD associated cough and asthma subjects, unlike those with positive endoscopy findings who revealed significant obstructive pattern when compared to those with negative endoscopy findings. Conclusions: GERD associated cough and asthma subjects with positive endoscopy findings showed obstructive pattern of spirometry irrelevant to the presence or absence of symptoms or duration of the disease.Key words: Gastroesophageal Reflux Disease, chronic cough, asthma.

الخلفية :إن الجزر المعدي المريئي قد يؤدي إلى مضاعفات في المرئ مثل الالتهاب , تقرحات ,تضيق ونزف المرئ وممكن أن تمتد ھﺬه المشاكل إلى أجزاء خارج المرئ وقد تكون سببا في السعال المزمن والربو القصبي .الأهداف :تقييم صورة وظائف الرئة في مرضى الجزر المعدي المريئي المرتبط بالسعال والربو القصبي وعلاقتها مع مؤشر كتلة الجسم , مدة المرض ووجود أو غياب الأعراض مع نتيجة فحص التنظير الداخلي .الاشخاص وطريقة العمل :تم اختيار تصميم دراسة المقطع العرضي الوصفي واجريت الدراسة في مستشفى ابن سينا التعليمي في الموصل . شملت الدراسة تسعون شخصا تتراوح اعمارهم بين (19- 65 سنة) من كلا الجنسين 35 شخصا كعينة ضابطة و55 مريضا يعانون من الجزر المعدي المريئي والسعال والربو وبعد أخذ جميع المعلومات اجري فحص وظائف الرئة لجميع المشمولين بالدراسة ثم اجري للمرضى ناظور المعدة .النتائج:أظهرت نتائج وظائف الرئة للعينة الضابطة أنها ضمن المدى الطبيعي (80-120%)مما يؤكد عدم وجود أي مرض في الرئة بينما كانت نتائج وظائف الرئة (FVC و ( FMF, PEF,FEV1% للمرضى منخفضة معنويا مع وجود تحدد واضح في وظائف الرئة لدى المرضى ذوو كتلة الجسم العالية .و وجود نمط انسدادي في وظائف الرئة لدى المرضى اللذين كان فحص الناظور موجب بالمقارنة مع المرضى اللذين كان فحص ناظور المعدة لهم سالب. الاستنتاج: إن وظائف الرئة لمرضى الجزر المعدي المريئي ذوو نتيجة ناظور معدة موجبة أظهرت نمط انسدادي بغض النظر عن وجود أو غياب اعراض المرض أو مع مدة المرض .انخفاض قيم وظائف الرئة للمرضى اللذين كانوا يعانون من الجزر المعدى لفترة اطول من ثلاثة اشهر عند مقارنتهم مع المرضى اللذين كانت فترة مرضهم اقل. مفتاح الدلالة:الجزر(الاسترجاع) المعدي المريئي ,السعال المزمن ,الربو.

Keywords

Background: Gastroesophageal reflux disease can lead to esophageal complications --- including esophagitis --- ulceration --- stricture --- hemorrhage --- and Barrett's esophagus. However --- the spectrum of problems associated with GERD has expanded to extra esophageal sites. Chronic cough and asthma are two clinical problems caused or triggered by GERD. Spirometric changes among GERD associated cough and asthma still a topic of ongoing research. Objectives: This study was designated to evaluate the spirometric picture of GERD associated cough and asthma subjects in relation to different clinical aspects of the disease including body mass index --- BMI --- disease duration --- presence or absence of symptoms as well as endoscopic findings. Subjects and methods: Ninety adult subjects --- 90 of either sex with a mean age of 40.5±12 year are involved in this study. Fifty five --- 55 GERD associated cough and asthma subjects served as test group while the remaining --- 35 served as control group. Each subject underwent spirometry and gastric endoscopy in Pulmonary Function and Endoscopy Units respectively at Ibn-Sina Teaching Hospital /Mosul. Results: Spirometric data of the control group were within the normal predicted range --- 80-120% thus excluding the possibility of any asymptomatic obstructive airway disease. Whereas --- the measured spirometric parameters --- forced vital capacity --- FVC --- forced expiratory volume in 1 second ratio --- FEV1% --- peak expiratory flow --- PEF --- and forced mid expiratory flow --- FMF are significantly reduced in the test group with a clear restrictive pattern among the overweight subjects. In addition --- neither the presence nor duration of symptoms affected the spirometric picture of the GERD associated cough and asthma subjects --- unlike those with positive endoscopy findings who revealed significant obstructive pattern when compared to those with negative endoscopy findings. Conclusions: GERD associated cough and asthma subjects with positive endoscopy findings showed obstructive pattern of spirometry irrelevant to the presence or absence of symptoms or duration of the disease. Key words: Gastroesophageal Reflux Disease --- chronic cough --- asthma. --- الجزرالاسترجاع --- المعدي المريئي --- السعال المزمن --- الربو.

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