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Article
The Relationship between the Presence of Uterine Fibroid and Symptoms in Women 20-40 Years Old

Authors: Muna Kasim Mahmood --- Zena Mahdi Abd Ali
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 1 Pages: 1793-1796
Publisher: Kerbala University جامعة كربلاء

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Abstract

Abstractbackground: we examined the prevalence of uterine fibroid and menstrual cycle characteristics in a population of non-care-seeking women.Methods: this is a cross- sectional study involves 175 women who were not lactating or using contraception and their age between 20-40. After taking history transvaginal ultrasound done to these female. We examined the association between menstrual cycle characteristic and the presence of uterine fibroid.Results & discussion: uterine leiomyomata were detected in 31 women (17.71%). The presence of uterine leiomypma was not significantly related to amount of blood loss with menstrual cycle, regularity of the cycle, dysmenorrheo or deep pelvic pain.Conclusion: in this population of non-care seeking women, menstrual cycle abnormalities are not related to the presence of uterine leiomyoma.Keywords: Uterine Fibroid, Menstrual cycle, uterine, Leiomypma


Article
Myomectomy During Early Pregnancy(Case report)

Author: Dr. Samar D. Sarsam
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 100-102
Publisher: Baghdad University جامعة بغداد

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Abstract

Myoma is a common benign uterine tumor; therefore it is common in pregnancy. One in ten women will have complications related to myoma in pregnancy. Few treatment options are available during pregnancy, conservative treatment with analgesia, reassurance and supportive therapy is almost always adequate but in carefully selected patients, myomectomy has been performed successfully without jeopardizing pregnancy outcome. The usual indications for surgery during pregnancy include torsion of pedunculated uterine myoma and obstructed labor, surgical intervention during pregnancy is occasionally necessary in uncommon cases of intractable pain.
19 years old lady presented with intractable lower abdominal pain during pregnancy. Ultrasound showed fetus of 18 weeks gestation and ovarian cyst. The pain did not respond to rest and sedation, so emergency exploration laparotomy was done; incarcerated intramural uterine myoma was the cause of the pain, it was enucleated successfully through myomectomy and the pregnancy progressed normally.
Keywords: Pregnancy, uterine fibroid, myomectomy.


Article
Study of Lipid Profile in Patients with Uterine Fibroid

Author: Lilyan W. Sersam
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 2 Pages: 274-279
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Leiomyomas are the most common gynaecological neoplasms. Despite the major public health impact of leiomyomas, little is known about their cause. As fibroids are hormone-dependent tumours and their development can be promoted by estrogens, an inverse association between hypercholesterolemia and fibroids should be observed as well as direct association between high-density lipoprotein cholesterol (HDL-C) levels and the presence of fibroids.OBJECTIVE:To investigate the lipid profile in patients with uterine fibroids and to compare it with the lipid profile of women without fibroids.METHODS:A case-control study was conducted in the Department of Obstetrics and Gynaecology at Al-Yarmouk Teaching Hospital during the period from May 2008 to May 2009. Participants were one-hundred twenty pre-menopausal women aged between 18 and 45 years who were recruited during their visit to the gynaecological outpatient clinic and were not taking hormonal therapy. Cases consisted of 60 women with uterine fibroids, and controls were 60 women visiting the same gynaecological outpatient clinic for routine reasons. Thorough history and examination was done for each participant. Body Mass Index (BMI) was measured in kg/m2. All patients underwent a baseline ultrasound examination and classified into two groups according to the presence or absence of uterine fibroids. All women where scheduled to undergo blood test at the beginning (2nd -5th day) of their next menstrual cycle. Fasting venous blood glucose and lipid profile were determined in blood samples taken for each patient. Atherogenic index was also calculated.RESULTS:Women with uterine fibroids were found to have significantly higher levels of serum HDL-C compared to the controls (P=0.0001). A significantly lower levels of total serum cholesterol, low-density lipoprotein cholesterol (LDL-C) were also found in women with uterine fibroids compared to the controls (P=0.0001). Atherogenic index was significantly lower in fibroid group compared with controls (P=0.0001). There was a significant positive correlation between largest fibroid volume and HDL-C level (P<0.0001).CONCLUSION:Women with uterine fibroid have lower atherogenic index compared to women without uterine fibroid. Larger volume of fibroid is associated with higher level of HDL-C.


Article
STUDY THE EFFECTS OF DRENCHING OF ETHANOLIC EXTRACT OF TARAXAC UM OFFICINALE LEAVES AND ATROVASTATIN ON SERUM ENZYMATIC ACTIVITY CHOLESTEROL LEVEL; REPRODUCTIVE EFFICIENCY AND ON THE STRUCTURAL CHARACTERISTICS OF PITUITARY-THYROID-OVARIAN-UTERINE AXIS OF LOCAL ADULT CHOLECYSTOCTOMISED FEMALE RABBITS
دراسة تاثير تجريع الخلاصة الكحولية لاوراق نبات الهندباء البرية وعقار الانورفاستاسين على نشاط انزيمات وكولسترول مصل الدم والكفاءة التناسلية وعلى الصفاة التركيبية لمحور النخامية -الدرقية-المبيض ورحم الارانب البالغة المزالة المرارة

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Abstract

This study had been done on twenty four healthy adult local female rabbits of_ mean body weight of 2 kgm and mean age of 5 months were randomly allocated into fourgroups of six ainmals eash; all groups were fed during the period of experiment on a dietcontained 0.5 % cholesterol and 14% coconut oil. The first group was regarded as controland received 3ml of physiological saline orally‘ for a month. The second group wasdrenched ethanolic extract of Taraxacum ojficirzale (500 mg/kg/day) for one month; thethird group first subjected to cholecystoctomy (removal of gall bladder) then drenched 500mg/kg/day ethanolic extract of T. oflicinale for month also. The fourth group was treatedwith atrovastatin (0.4 mg/kg/day) for one month also. Those females were joined withmales after treatment for a week to study the effect on fertility and reproductive capacityand on fetal growth. Blood samples were taken from all groups at the end of the treatmentto know the effect on serum cholesterol and on enzymatic activity then after killing theanimals the following organs were taken for histological study.They are pituitary and thyroid glands; ovaries and uterin from each animal of each. group. The following results were obtained:-1. The ethanolic extract of Taraxacum ofiicinale caused highly significant increase(p<0.01) in SGOT.2. Atrovastatin caused significant increase i(p<0.05) in SGOT.3. Drenching Tofiicinale extract didnot cause any significant change in SGOT ofcholecystoctomised female rabbits. ’4. The ethanolic extract of Tofficinale and atorvastatin had caused significant decrease(p<0.05) of SGPT in intact female rabbits but caused highly significant decrease

Keywords

Uterine --- Enzymes --- extract


Article
A case of Giant Uterine Fibroid in a Young Woman

Authors: Safa M.Al-Obaidi --- Mohammed Abd-Zaid Akool
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 4 Pages: 588-592
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:The incidence of uterine fibroid tumor increase as women grow older and they may occur in more than 30 percent of women 40 to 60 years of age. Risk factors include nulliparity, obesity, family history, black race, and hypertension.These neoplasms frequently cause abnormal period, pelvic pain, and pressure symptoms. We present a case report of a large leiomyoma in an adult woman


Article
ENDOMETRIAL POLYP WITH ENDOMETRIAL HYPERPLASIA &CHRONIC INFLAMMATION IN RABBITS
الأورام الأنبوبية لبطانة الرحم وفرط التنسج والالتهاب المزمن لبطانة الرحم في الأرانب

Author: Asmaa Sh.Aliawy اسماء شرهان زبون العلياوي
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2012 Volume: 11 Issue: 2 Pages: 10-16
Publisher: Basrah University جامعة البصرة

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Abstract

Rabbits were treated with large does of progesterone for up to 420 days developed numerous cysts of the endometrial ,sometimes associated with atypical .Histological of examination was performed on uterine biopsy samples of irregular cystic (polyp) masses noted .During caesarean section of a 2 month –old female Rabbits ,Microscopically examination revealed dilated hyperplasia gland with focal back to tack appearance ,surrounded by spindle ,fibrocystic-like cells ,stroma, heavy plasma cells infiltration of the endometrial by widely scattered viable and degenerate neutrophils ,lymphocytes , and plasma cells admixed with mild amounts of cellular debris and hemorrhage. The endometrial was markedly expanded by many irregular polyps and hyperplasic gland .Grossly one uterus was slightly thickened with pale mucous membranes .Where as the other uterus had numerous small ,4 mm in diameter, translucent cysts diffusely scattered on the endometrial surface .2x1.5x1 cm polyp oval ,hard, gray-blue smooth surface. Shows pink and bluish thin with small cysts.

Keywords

Rabbits --- polyp --- Uterine.


Article
Abnormal Uterine Bleeding: a Histopathological Study
النزيف الرحمي غير الطبيعي –دراسة نسيجية

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Abstract

Background: Abnormal uterine bleeding (AUB) is considered as one of the most common and perplexing problems both to the patient and the gynecologist. Until the pathology underlying menorrhagia is accurately diagnosed, proper therapy is hardly possible.Objective: The objectives of the study were to determine the types and frequencies of pathologies in endometrial curettings of abnormal uterine bleeding & compare different endometrial pathologies in patient to age groups.Material and Methods: a retrospective study in which H&E sections of endometrial curretings of 152 patients were evaluated. Diagnosis was made by correlating the morphological findings with the clinical history. Results: Out of 152 cases of AUB, 61.8% were due to organic causes, while 33.5% were dysfunctional in nature and seven (4.6%) specimens were insufficient for diagnosis. Of the organic causes of AUB, Table (3), low grade endometrial hyperplasia was the most frequent cause (41.5%) then pregnancy-related bleeding (31.9%). The most common histologic pattern in DUB was proliferative phase endometrium 45.1%, followed by secretory pattern 21.6%.Conclusion: Our study on endometrial curettings in abnormal uterine bleeding revealed clustering of cases around Perimenopause.

يعتبر النزيف الرحمي غير الطبيعي نتيجة الأعتلال الوظيفي من المشاكل الشائعة والمحيرة للمريضة وأخصائي الأمراض النسائية والمعالجة الصحيحة تكون صعبة بدون تشخيص السبب الرئيس للنزيف و يهدف الى تحديد أنواع وأعداد الأمراض والعوامل المسببة للنزيف الرحمي غير الطبيعي في نماذج تجريف بطانة الرحم ومقارنة كل هذه الأسباب مع مجاميع العمر للمريضات حيث تم استخدام وأعاده تقييم المقاطع النسيجية المصبوغة بصبغة الهيماتوكسيلين والأيوسين لنماذج تجريف بطانة الرحم الخاصة ب 152 مريضة وتم التشخيص بربط التغيرات النسيجية المرضية مع العوامل السريرية للمرض . وجد انه من ضمن 152 مريضة كانت نسبة 61.8% من الحالات لأسباب عضوية بينما 33.5% من الحالات كانت الأسباب نتيجة اعتلال وظيفي لبطانة الرحم. فيما كانت 7 نماذج (4.6%) غير كافية للتشخيص. من الأسباب الوظيفية(جدول رقم 3 ) كان السبب الشائع للنزيف الرحمي غير الطبيعي هو فرط الأستنساج لبطانة الرحم ذو المرحلة الواطئة ( 41.5%) بعد ذلك أسباب النزيف الرحمي المتعلق بأمراض الحمل (31.9%), وكانت غالبية النماذج النسيجية من نزيف الرحم غير الطبيعي هو من الطور المتنامي لبطانة الرحم (45.1%), يتبعه الطور الأفرازي بنسبة 21.6%. في دراستنا لنماذج تجريف بطانة الرحم فيما يخص النزيف الرحمي غير الطبيعي لوحظت الغالبية من الحالات في الفئة العمرية القريبة من سن اليأس .


Article
Assessment of three methods of curetting orientation for women with excessive uterine bleeding
تقييم ثلاث طرق لcuretting orientation للنساء مع نزيف الرحم المفرط

Authors: Hersh Rasul ----- --- Rafal Abdul Razaq Al-rawi
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2013 Volume: 17 Issue: 3 Pages: 502-507
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Dilation and curettage (D&C) is commonly performed for the diagnosis of gynecological conditions leading to excessive uterine bleeding. The aim of this study was to evaluate different methods of curetting orientation to optimise the diagnosis of common pathological lesions associated with excessive uterine bleeding.Methods: Data and cases retrieved from women presented with excessive uterine bleeding and underwent D&C, at a private histopathology laboratory in Erbil city, Kurdistan region, from December 2010 to January 2012. Three methods of curetting orientation were carried out on 275 patients. Light microscopical study was done to asses the cause of excessive uterine bleeding.Results: A total of 274 out of 275 cases were found to have optimal tissue processing, embedding and histological examination. When the tissue specimens attached to filter paper and gauze, two out of 275 cases were found to have endometrial adenocarcinoma. Moreover, out of 275 cases, 198 were found to have dysfunctional uterine bleeding (hormonal imbalance) and 25 cases were found to have endometrial hyperplasia.Conclusion: Optimal tissue processing, embedding and histological orientation can be attained by using filter paper and/or gauze. Dilation and curettage is an adequate diagnostic tool for endometrial hyperplasia and carcinoma.


Article
Goserelin versus Norethisterone in the Management of Menorrhagia with Uterine Fibroid

Authors: Yousif Abdul-Raheem --- Jwan N. Sulaiman --- Faris A. Rasheed
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 2 Pages: 54-58
Publisher: Baghdad University جامعة بغداد

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Abstract

Menorrhagia is common in patients with uterine fibroids, if operation needs to be delayed for a particular reason, goserelin can be used safely to reduce bleeding and the size of the tumor.The objective is to compare between goserelin acetate and norethisterone on patients with menorrhagia and uterine fibroid. A randomized controlled study conducted in Elwiya maternity teaching hospital, Baghdad from the first of November 2007 to the end of April 2009. 90 patients from the consultant outpatient clinic with menorrhagia and fibroid, and their operations were delayed for medical reason were allocated in two groups, the first group, was given 3.2 mg goserelin acetate subcutaneously monthly for 3 months and the second group was given 5 mg norethisterone orally three times daily during the attack of bleeding and 5 mg once daily, cyclically if no bleeding for 3 months. The fibroid was measured in two dimensions, using convex real-time ultrasound before treatment and three months after treatment. Haemoglobin and the number of pads used were also reported before and after treatment, also the side effects in both groups and the need for operations.The size of fibroid in two dimensions measurement was reduced from 28.24 cm2 ± 6.14 to 12.3 cm2 ± 3.45 in the goserelin group (P=0.0001) versus 26.56 cm2 ± 5.96 to 25.22 cm2 ± 5.01 in the norethisterone group (P= 0.2589). The haemoglobin level was 9.28 gm/100ml ± 2.44 pre-treatment in the goserelin group and 11.2 gm/100ml ± 1.88 post-treatment (P= 0.0001) versus 10.08 gm/100ml ± 2.86, and 10.24 gm/100ml ± 2.46 respectively in the norethisterone group (P= 0.7798). The need for operation was decreased significantly in the goserelin group. Goserelin showed better patient response and reduction in the tumor size than norethisterone in treatment of patients with menorrhagia and uterine fibroids if operation is delayed for medical or other reasons.

إن دواء كوزرلين ( Goserlin ) يظهر نتائج أفضل من دواء ( نوراثي ستيرون ) Norethisterone في معالجة وتقليص حجم العقد الليفية في الرحم و خاصة عند المريضات اللواتي يعانين من نزف شديد أثناء الدورة الشهرية أو هناك أسباب طبية تؤدي إلى تأجيل عملية رفع العقد الليفية جراحياً . ووجد أن إعطاء دواء ( الكوزرلين ) ) Goserlin ) لمدة 3 أشهر فعال في معالجة المريضات اللواتي يعانين من نزف شديد أثناء الدورة الشهرية بسبب وجود عقد ليفية على الرحم إذ وجد انه يقلل من شدة النزف ويرفع من نسبة الهيموكلوبين بالدم مما يقلل الحاجة إلى إعطاء دم أو اللجوء إلى التداخل الجراحي مع وجود إعراض جانبية طفيفة .


Article
Fibrinolysis in idiopathic menorrhagia

Authors: Muna A. Kashmoola منى كشمولة --- Maida Shamdeen مائدة شمدين
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 2 Pages: 62-65
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: the role of fibrinolysis in idiopathic dysfunctional uterine bleeding (IDUB).
Design: prospective clinico-haematological study.
Setting: patients were collected in Albatool maternity teaching hospital; a haematological study was conducted in Ibn Sina teaching hospital in Mosul from 10th January to 10th of June 2004.
Participants: 53 patients with mean age of 40.5 years and a range of 15-54 years, complaining of idiopathic dysfunctional uterine bleedings(IDUB) served as experimental group, and 30 presumed healthy women served as a control group, their ages were between 18-45years. After exclusion of organic causes, drugs, IUCD, medical causes, and bleeding tendency, blood samples were tested for haemoglobin, plasma D-dimer test and plasma fibrinogen.
Results: D-dimer test was positive in 16 out of 53 cases (30.2%) of experimental group (Group 1). It was significantly positive (p< 0.005) in cases of idiopathic menorrhagia compared to the control group. D-dimer test was significantly positive in those with prolonged duration of vaginal bleeding >7days, compared to those with heavy periods and short duration of vaginal bleeding (p<0.05), D-dimer test was negative in the remaining cases (group II). The fibrinogen level was significantly lower in patients with positive D-dimer (p<0.05). Antifibrinolytic agent tranexamic acid was given to all patients in both groups; 93% of women responded to the treatment in group 1, while the response in group II was 54%.
Conclusion: Idiopathic menorrhagias appear to be due to increased fibrinolytic activity; such patients are likely to benefit from antifibrinolytic agents.

Keywords: Menometrorrhagia, dysfunctional uterine bleeding, fibrinolysis.

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