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Association of Vitamin D Metabolite Levels with Relapse Rate and Disability in Multiple Sclerosis

Authors: Akram M. Al-Mahdawi --- Gheyath Al Gawwam --- Raad A. Al Ethawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 3 Pages: 298-305
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Multiple sclerosis is an inflammatory demyelinating disease of the central system. It estimated to affect more than 2・5 million people worldwide. It is the most common non-traumatic cause of disability in young adults. Although the cause of multiple sclerosis remains undetermined, number of risk factors for MS have been identified and they can loosely be put into one of two categories; genetic or environmental components. Epidemiologic studies have suggested there is an increase in incidence and prevalence of MS with increasing latitude north and south of the equator. Latitude has implicate vitamin D status as a determinant of risk.OBJECTIVE:To study the association of vitamin D level with relapse rate and disability in patients with relapsing remitting multiple sclerosis in Iraq.PATIENTS AND METHODS:Thirty patients (6 males and 24 females) with relapsing remission multiple sclerosis (RRMS), their age range from 16 to 45 years, recruited from MS clinic of neurology department of Baghdad teaching hospital in the medical city in Baghdad and twenty five completely healthy controls (6 males and 19 females) from general population and their age range from 20 to 40 years were enrolled in this study in the period from April 2011 to the end January 2012. RESULTS:The present study shows low vitamin D levels for both patient with RRMS and control group. There is significantly lower 25(OH)D level in patients with relapse compared with patients without relapse in the last 6 weeks. Also we found higher expanded disability status scale (EDSS) in patients with relapse compared with patients without relapse in the last 6 weeks. Lastly, we didn’t find any correlation between vitamin D level and EDSS in patients group study.CONCLUSION:We concluded from this study that there is low circulating level of 25(OH)D in RRMS patients, especially during relapses. Also there is no effect of vit D on disability


Article
Association of Serum Levels of 25 Hydroxyvitamin D and Type 2 Diabetes Mellitus: Age and Gender Dependent Study

Author: Thana I Mustafa*, Basil O Saleh**, Abid A Thaker***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2017 Volume: 16 Issue: 2 Pages: 138-143
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Vitamin D deficiency has been found to have an inverse relationship with the occurrence of diabetes mellitus (DM). The aims of this study were to investigate the serum levels of vitamin D in type 2 DM and to correlates the obtained values with their age and gender.SUBJECTS AND METHODS: This case-control study was carried out at Al-Ramadi General Teaching Hospital, and the National Diabetes Center for Treatment and Research at Al- Mustansiriya University, Iraq, during the period from December 2014 to November 2015. It involved, 80 patients with type 2 DM, and 60 healthy subjects. Investigations included serum measurement of 25 Hydroxyvitamin D (25OHD), fasting glucose, Insulin, glycated hemoglobin (HbA1c) in all patients and controls using ELISA technique.RESULT: The median concentration of serum 25 OHD of patients with type 2 DM (15.70 ng/ ml) were significantly lower than that of healthy controls (20.27 ng/ ml, P= 0.001). The rate of vitamin D deficiency (VDD) was significantly higher in type 2(82.5%) diabetic patients than in healthy controls (48.3%, P=0.001). Type 2 diabetic patients with age of 60 years and above and female had the highest VDD compared to others, type 2 diabetic patients with age of ≥ 60 years increased the risk of having VDD by 9.8 times compared to those with age group <18 years, but still insignificant (P =0.07).CONCLUSION: The results revealed significant deficiency of serum vitamin D in diabetic patients type 2. Supplementation of vitamin D may improve the control of this syndrome or even delay its incidence and complication. .

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